I am a power user of Firefox; it is not uncommon for me to have 30 tabs open. But with convenience comes problems. Memory problems. As the tabs are cycled through, closed, opened anew, the memory Firefox grabs grows (though it seems better in v3.5). One modification you can do is this:
1. In the url bar type in: about:config
2. Accept the warning.
3. Right-click on the resulting page and add New > Boolean
4. As the preference name enter: config.trim_on_minimize
5. Choose True as the value.
6. Restart Firefox.
Now when Firefox is minimized it frees up memory.
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